IMPLICATION OF MEAN PLATELET VOLUME AND PLATELET COUNT IN DENGUE PATIENTS

ARTICLE HISTORY: Submission: Jan 9, 2025, Revision: Feb 10, 2025, Acceptance: Feb 24, 2025; DOI Information: https://doi.org/10.56815/ijmsci.v5i1.2025.1-8

Authors

  • Dr. Kaviya Priyadarshni K Postgraduate, Department of Pathology, Vinayaka Missions Medical College and Hospitals, Karaikal, Pondicherry, India.
  • Dr. Shilpa T Patil Associate Professor, Department of Pathology, Vinayaka Missions Medical College and Hospitals, Karaikal, Pondicherry, India.
  • Dr. Janakiraman K Assistant Professor, Department of Pathology, Vinayaka Missions Medical College and Hospitals, Karaikal, Pondicherry, India.
  • Dr. Anusha N Professor & Head, Department of Pathology, Vinayaka Missions Medical College and Hospitals, Karaikal, Pondicherry, India.

Keywords:

Dengue fever, Thrombocytopenia, Mean platelet volume, Platelet count, Prognosis

Abstract

Background: Dengue fever (DF) is a viral infection endemic to many tropical regions, including Southeast Asia, and is characterized by a range of clinical manifestations, from mild febrile illness to severe dengue hemorrhagic fever (DHF). Thrombocytopenia is a common hallmark of dengue, with platelet count and mean platelet volume (MPV) being potential markers for disease prognosis. Objective: This study aims to evaluate the association between platelet count and MPV in dengue patients to assess their prognostic utility. Methods: A prospective study was conducted at Vinayaka Mission’s Medical College & Hospital, Karaikal, from July 2023 to September 2023, involving 60 confirmed dengue patients. Platelet count and MPV were measured using the Mindray BC 6000 hematology analyzer. Statistical analysis was performed using SPSS 23.0, with ANOVA and t-tests used to assess the significance of the association between platelet count and MPV, and p-values < 0.05 considered significant. Results: The study included 33 males and 27 females. 85% of cases shows the MPV values between 8-12 and 50% cases had platelet count between 50000-100000. A significant relation was found between MPV and platelet count indicating that as platelet count decreased, MPV increased. Conclusion: MPV and platelet count are inversely related in dengue patients. However, platelet count and MPV were not influenced by age. These results highlight the potential of MPV as a prognostic tool in dengue management. Further research is needed to explore its role in predicting disease severity.

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