A COMPREHENSIVE REVIEW ON SUPERDISINTEGRANTS: ACCELERATING DISSOLUTION FOR ENHANCED DRUG PERFORMANCE

Article History: Submission: 19-03-2024, Revision: 01-05-2024, Acceptance: 29-05-2024, DOI Information: https://doi.org/10.56815/IJMSCI.V4I1.2024/34-49

Authors

  • Lalita Tyagia Department of Pharmacy, Meerut Institute of Engineering and Technology (MIET), Meerut-250005, U.P, India.
  • Priyanshub Department of Pharmacy, Kalka Institute for Research and Advanced Studies (KIRAS), Meerut-250005, U.P, India.

Keywords:

Superdisintegrants, Drug dissolution, Croscarmellose sodium, Sodium starch glycolate, Crospovidone, Disintegration mechanisms, Synthetic superdisintegrants, Natural superdisintegrant, Semi-synthetic superdisintegrants, Disintegration

Abstract

To improve medication bioavailability and therapeutic efficacy, oral dosage forms must dissolve quickly and effectively. Drug release from solid formulations can be accelerated with the use of superdisintegrants, which are specialized chemicals that encourage disintegration. This study offers a thorough analysis of superdisintegrants, emphasizing their kinds, uses in pharmaceutical formulations, and modes of action. Superdisintegrants that speed up tablet breakdown, such as crospovidone, sodium starch glycolate, and croscarmellose sodium, enable quicker dissolving and absorption. Superdisintegrants are classified as natural, semi-synthetic, synthetic, and co-processed in the review, which also discusses their special qualities, benefits, and drawbacks. The physicochemical characteristics of the medicine and a number of other factors affect how well superdisintegrants promote disintegration. The drawbacks, such compatibility problems and possible impacts on medication stability, must be carefully considered despite their advantages. In addition, this review discusses current studies and potential directions for creating and using superdisintegrants for improved drug delivery systems. In order to facilitate the creation of high-performance medication formulations and enhance patient compliance and treatment results, this thorough review attempts to deepen our understanding of the roles and functions of superdisintegrants.

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